Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2552115 | Life Sciences | 2010 | 7 Pages |
Abstract
AimWe investigated the expression pattern of Notch-1 in normal and hypertrophied plantaris muscle of mice.Main methodsWe performed immunofluorescence of both Notch-1 and the Notch-1-linking molecules.Key findingsImmunofluorescence labeling revealed Notch-1 protein in Pax7-positive satellite cells during days 2–6. We observed clear co-localization between Notch-1 and myogenin (4.9 ± 1.3%) in the hypertrophied muscle at 4 days. Several mononuclei (possibly satellite cells) possessed both Notch-1 and Foxo1 in the plantaris muscle subjected to mechanical overloading (4.1 ± 1.2%).SignificanceNotch-1 may play an important role in the maintenance of quiescent satellite cells.
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Authors
Mai Akiho, Hiroyuki Nakashima, Munehiro Sakata, Yuka Yamasa, Akihiko Yamaguchi, Kunihiro Sakuma,