Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2552487 | Life Sciences | 2008 | 4 Pages |
Abstract
Tyrosinase is a rate-limiting enzyme in mammalian melanogenesis, and is known as a glycoprotein. Post-translational processing of mammalian tyrosinase is required for its folding, sorting, and for enzymatic activity. Here we show for the first time that the mammalian tyrosinase has β1,6-branched N-glycan structure that can be recognized by binding with specific lectin Leukoagglutinating phytohematoagglutinin (L-PHA). Further, this specific glycoconjugate structure has been shown to have a function relationship in melanin synthesis.
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Authors
Debjit Chakraborty, Ashok K. Chakraborty,