On the mechanisms of arrhythmias in the myocardium of mXinα-deficient murine left atrial-pulmonary veins

The fact that AF could be induced by fast pacing under several conditions in mXinα+/+ but not in mXinα−/− LA-PV preparations appears to be due to a slower CV, a prolonged APD90, a less negative MDP and possibly larger areas of conduction block in mXinα−/− myocardial cells. In contrast, the non-impairment of automatic and triggered rhythms in mXinα−/− preparations may be due to the fact that the mechanisms underlying these rhythms do not involve cell-to-cell conduction.