| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2552920 | Life Sciences | 2008 | 8 Pages |
Abstract
We investigated the role of the hypothalamic supraoptic nucleus (SON) in nociception in the rat. Electrical stimulation of the SON or microinjection of a small dose of l-glutamate sodium into the SON elevated the nociceptive threshold in a dose-dependent manner, while cauterization of the SON decreased the nociceptive threshold. Pituitary removal did not influence the antinociceptive effect of l-glutamate sodium in the SON. The data suggested that the neurons and not the nervous fibers in the SON played an important role in antinociception.
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Authors
Jun Yang, Yu Yang, Jian-Min Chen, Wen-Yan Liu, Bao-Chen Lin,