Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2553411 | Life Sciences | 2007 | 5 Pages |
Regulation of intracellular concentrations of cyclic AMP is one of the most ubiquitous mechanisms for regulating cellular functions. Further, the manner in which cAMP production is regulated via G proteins at the level of adenylyl cyclase activation has been studied extensively. This review focuses instead on the recently identified mechanisms and roles for regulation of adenylyl cyclase functions beyond G protein activation. These mechanisms include: a) the coupling of particular isoforms of adenylyl cyclase to function within a single cell type b) regulation of membrane trafficking of higher order enzyme aggregates and c) raf kinase-dependent phosphorylation and sensitization of adenylyl cyclases — an important pathway for crosstalk between tyrosine kinase signaling cascades with regulation of cAMP-mediated responses.