Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2554664 | Life Sciences | 2006 | 6 Pages |
Abstract
Annonaceous acetogenins are a group of potential anti-neoplastic agents isolated from Annonaceae plants. We purified squamocin, a cytotoxic bis-tetrahydrofuran acetogenin, from the seeds of Annona reticulata and analyzed its biologic effects on cancer cells. We showed that squamocin was cytotoxic to all the cancer lines tested. Furthermore, squamocin arrested T24 bladder cancer cells at the G1 phase and caused a selective cytotoxicity on S-phase-enriched T24 cells. It induced the expression of Bax and Bad pro-apoptotic genes, enhanced caspase-3 activity, cleaved the functional protein of PARP and caused cell apoptosis. These results suggest that squamocin is a potentially promising anticancer compound.
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Authors
Shyng-Shiou F. Yuan, Hsueh-Ling Chang, Hsiao-Wen Chen, Fu-Chen Kuo, Chih-Chuang Liaw, Jinu-Huang Su, Yang-Chang Wu,