Low-density lipoprotein receptor-related protein 5 variant A1330V is a determinant of blood pressure in Japanese males

We examined the influence of the A1330V variant in the low-density lipoprotein receptor-related protein 5 gene on blood pressure in a large cohort of Japanese workers. This study used analysis of covariance in a multivariate general linear model to adjust for other potential factors such as age, body mass index, blood chemistry and lifestyle. The target subjects were 1440 males and 1169 females selected from 3834 male and 2591 female workers in a single company. Hypertension was defined as systolic blood pressure ≥ 140 mm Hg and/or diastolic blood pressure ≥ 90 mm Hg or the use of antihypertensive medications. Genotype distributions for A1330V in hypertensive males (AA = 139(54.5%), AV = 101(39.6%), VV = 15(5.9%)) and females (AA = 48(63.2%), AV = 24(31.6%), VV = 4(5.3%)) were not significantly different from normotensive males (AA = 594(50.1%), AV = 488(41.2%), VV = 103(8.7%)) and females (AA = 568(52.0%), AV = 441(40.3%), VV = 84(7.7%)). Allele distributions were not significantly different in either sex. In males, analysis of covariance showed that the VV genotype was associated with a 2.5 mm Hg lower diastolic blood pressure and a 2.3 mm Hg lower mean blood pressure than the AA genotype. This study indicates that the 1330V allele is an independent factor for lower diastolic and mean blood pressure in Japanese males.