Oxidative stress in patients with primary insomnia

ObjectiveMany physiological and pathological processes, such as infections, environmental toxins, and ionizing radiation increase bodily concentrations of oxidizing substances, known as free radicals, which lead to neurodegenerative disorders. Sleep is one of the most important factors contributing to health; however, insomnia is among the most prevalent health complaints.MethodsIn this study, for the first time in the literature, we investigated the effects of primary insomnia on certain oxidative stress biomarkers. For this purpose, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and myeloperoxidase (MPO) activities and levels of reduced glutathione (GSH) and malondialdehyde (MDA) were measured in 30 patients with primary insomnia and 30 healthy volunteersResultsOur results show that the patients with primary insomnia had significantly lower GSH-Px activity and higher MDA levels compared with the controls.ConclusionThese results may indicate the important role of sleep in attenuating oxidative stress.

► We have investigated the effects of primary insomnia on oxidative stress markers. ► Thirty patients with primary insomnia and 30 healthy volunteers were evaluated. ► GSH-Px, SOD, and MPO activities and levels of GSH and MDA were measured. ► The patients had significantly lower GSH-Px activity and higher MDA levels. ► These findings seem to have implications for future sleep research.