| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2565186 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2010 | 6 Pages |
Abstract
The present study employs a conditioned place preference procedure (CPP) to examine the effects of exposure to the cannabinoid agonist WIN 55212-2 (WIN) (0.1 and 0.5 mg/kg) during adolescence on the reinforcing properties of ± 3,4-methylenedioxymetamphetamine hydrochloride (MDMA) (1.25 and 2.5 mg/kg) in mice. On postnatal day (PD) 27, animals received a daily injection of the assigned treatment on 5 consecutive days, and three days later the place conditioning procedure was initiated (PD 35). The results suggest that pre-exposure to cannabinoids strengthens the properties of MDMA and favors reinstatement of the craving for the drug, which endorses the gateway hypothesis.
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Authors
Marta Rodríguez-Arias, Carmen Manzanedo, Concepción Roger-Sánchez, Bruno Ribeiro Do Couto, María Asunción Aguilar, José Miñarro,