| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2565242 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2011 | 7 Pages |
Abstract
âºEgr-1 binding sequences in the GDNF promoter are necessary for optimal promoter activation by imipramine. âºInduction of Egr-1 by imipramine upregulate GDNF in a dose-dependent manner. âºImipramine-induced GDNF mRNA expression was strongly attenuated in primary astrocytes from Egr-1â/â mice. âºImipramine induction of Egr-1 occur through the MEK/ERK and JNK MAPK pathways in astrocytes.
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Authors
Yeni Kim, Se Hyun Kim, Yong Sik Kim, Young Han Lee, Kyooseob Ha, Soon Young Shin,