Article ID Journal Published Year Pages File Type
2565451 Progress in Neuro-Psychopharmacology and Biological Psychiatry 2009 5 Pages PDF
Abstract
We found that MAOA in combination with COMT appears to regulate not only the stress response in laboratory experiments, but also seems to influence the stress-evoked onset of mood during normal, mild, stressful events, such as experienced in the peripartum period. These findings support the G × E concept for depression, but they underline the complexity of this concept, as the cumulating effects of these polymorphic genes (i.e. MAOA + COMT) might be needed and the effects of these polymorphic genes becomes apparent in special environmental or physiological conditions (i.e. the peripartum period). We therefore suggest that G × E interactions become especially noticeable from longitudinal study designs in specific physiological or social challenging periods.
Related Topics
Life Sciences Neuroscience Biological Psychiatry
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