Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2565451 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2009 | 5 Pages |
Abstract
We found that MAOA in combination with COMT appears to regulate not only the stress response in laboratory experiments, but also seems to influence the stress-evoked onset of mood during normal, mild, stressful events, such as experienced in the peripartum period. These findings support the GÂ ÃÂ E concept for depression, but they underline the complexity of this concept, as the cumulating effects of these polymorphic genes (i.e. MAOAÂ +Â COMT) might be needed and the effects of these polymorphic genes becomes apparent in special environmental or physiological conditions (i.e. the peripartum period). We therefore suggest that GÂ ÃÂ E interactions become especially noticeable from longitudinal study designs in specific physiological or social challenging periods.
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Authors
Bennard Doornbos, D.A. Janneke Dijck-Brouwer, Ido P. Kema, Marit A.C. Tanke, Saskia A. van Goor, Frits A.J. Muskiet, Jakob Korf,