| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2565506 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2010 | 5 Pages |
Abstract
âºChronic fluoxetine treatment resulted in clinically-relevant plasma fluoxetine concentrations in male and female rats, and significantly decreased serotonin turnover in the prefrontal cortex. âºChronic fluoxetine treatment did not significantly alter erythrocyte fatty acid composition in male or female rats.âºChronic fluoxetine treatment significantly and selectively increased docosapentaenoic acid (22:5n-6) in the prefrontal cortex of female rats, but not in male rats.⺠These results do not support the hypothesis that chronic fluoxetine treatment increases omega-3 fatty acid biosynthesis or membrane composition.
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Authors
Robert K. McNamara, Jessica A. Able, Therese Rider, Patrick Tso, Ronald Jandacek,