Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2565620 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2008 | 7 Pages |
Abstract
The aim of this study was to evaluate whether deep white matter hyperintensities (DWMH) and periventricular white matter hyperintensities (PVH) are associated with suicidal behavior in patients with major affective disorders. Subjects were 99 consecutively admitted inpatients (42 men; 57 women; mean age: 46.5 years [SD = 15.2; Min./Max. = 19/79]) with a diagnosis of major affective disorder (bipolar disorder type I, bipolar disorder type-II and unipolar major depressive disorder). 44.4% of the participants had made at least one previous suicide attempt. T2-weighted brain magnetic resonance images were rated for the presence and extension of WMH using the modified Fazekas scale. Patients were interviewed for clinical data on average 5 days after admission. Bivariate analyses, corrected for multiple-testing, and logistic regression analysis were used to test the association between suicide attempts and clinical variables. Attempters and nonattempters differed only in the presence of PVH-the former were more likely to have PVH. The logistic regression indicated that the presence of PVH was robustly associated with suicidal behaviors after controlling for age (OR: 8.08). In conclusion, neuroimaging measures may be markers of risk for suicidal attempts in patients with major affective disorders.
Keywords
BD-IUnipolar major depressive disorderDWMHBipolar Disorder Type IDSM-IV-TRPVHWMHMDD95%CIχ2Chi-squared testwhite matter hyperintensitiesMajor depressive disorderbipolar disorderMajor affective disordersMRIMagnetic resonance imagesSuicideDiagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision95% confidence intervalsodds ratio
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Authors
Maurizio Pompili, Marco Innamorati, J. John Mann, Maria A. Oquendo, David Lester, Antonio Del Casale, Gianluca Serafini, Silvia Rigucci, Andrea Romano, Antonino Tamburello, Giovanni Manfredi, Eleonora De Pisa, Stefan Ehrlich, Giancarlo Giupponi,