Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2565634 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2008 | 6 Pages |
Abstract
It has been shown that the steroid dehydroepiandrosterone (DHEA) interacts with dopamine (DA) and serotonin (5-HT) neurotransmitter systems, which are involved in the pathophysiology of neurological and psychiatric diseases such as Parkinson's disease as well as mood and psychotic disorders. To explore if DHEA modulates DA and 5-HT metabolism we analyzed the content of both neurotransmitters and their metabolites in the rat corpus striatum (CS) and nucleus accumbens (NAc) 2 h after steroid administration (30, 60 and 120 mg/kg i.p.). DHEA treatment significantly reduced DA turnover (up to 33%) in the CS, but increased 5-HT turnover (up to 76%) in both regions. Those effects could be relevant to mood and neurodegenerative disorders.
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Biological Psychiatry
Authors
Iván Pérez-Neri, Israel Méndez-Sánchez, Sergio Montes, Camilo Ríos,