Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2566514 | Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2007 | 4 Pages |
Abstract
Corticotropin-releasing factor (CRF) is a key regulator of the stress response. We investigated the effects of the atypical antipsychotic drug quetiapine on CRF mRNA expression in the rat hypothalamus following immobilization stress. Pretreatment with 10 mg/kg quetiapine significantly reduced the immobilization stress-induced increase in CRF mRNA expression in the paraventricular nucleus of the hypothalamus. These results suggest that quetiapine may modulate the stress response via regulation of CRF mRNA expression.
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Authors
Sung-Woo Park, Sun-Kyung Lee, Jae-Min Kim, Ho-Cheol Kang, Jin-Sang Yoon, Young-Hoon Kim,