Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2566977 | Pulmonary Pharmacology & Therapeutics | 2015 | 8 Pages |
Abstract
Pulmonary hypertension (PH) is a rapidly progressive disease that eventually leads to right heart failure and death. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptors (TRAIL-Rs) play an important role in the survival, migration, and proliferation of vascular smooth muscle cells. However, the association between serum TRAIL levels and PH is unknown. In this study, we assayed the serum soluble TRAIL (sTRAIL) levels in 78 patients with PH and 80 controls. The sTRAIL concentrations were elevated in the PH patients compared with the controls (138.76 ± 6.60 pg/mL vs. 80.14 ± 3.38 pg/mL, p < 0.0001). The presence of sTRAIL levels of >103 pg/mL could discriminate PH patients from healthy individuals, with a sensitivity of 75.6% and specificity of 81.2%. Moreover, elevated sTRAIL concentrations were associated with eventual pathological complications; this is consistent with the finding that sTRAIL levels decreased in patients who responded to treatment. In a hypoxia-induced PH mouse model, sTRAIL levels were significantly higher compared with those in normoxia mice, and clearly decreased when the mice were treated with treprostinil. The sTRAIL levels were positively correlated with right ventricular systolic pressure and the index of right ventricular hypertrophy. In conclusion, serum sTRAIL could be a biomarker for diagnosis and effective therapy for PH patients.
Keywords
CTEPHPAHRVSPCTDRVHhs-CRPIPAH6MWDCHDLHDLVEFConnective tissue diseasecoronary artery diseaseCongenital heart diseasePulmonary artery smooth muscle cellCADPulmonary arterial hypertensionChronic thromboembolic pulmonary hypertensionTRAILtumor necrosis factor-related apoptosis-inducing ligandMouse modelRight ventricular hypertrophyPulmonary hypertensionIdiopathic pulmonary arterial hypertensionhigh-sensitivity C-reactive proteinleft ventricular ejection fraction
Related Topics
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Pulmonary and Respiratory Medicine
Authors
Huan Liu, Erli Yang, Xiaolan Lu, Caojian Zuo, Yuhu He, Daile Jia, Qian Zhu, Ying Yu, Ankang Lv,