A critical appraisal of methods used in early clinical development of novel drugs for the treatment of asthma

Article ID	Journal	Published Year	Pages	File Type
2567711	Pulmonary Pharmacology & Therapeutics	2007	19 Pages	PDF

Abstract

In this review, we provide a practical overview of the current status of various sampling techniques including sputum induction, exhaled breath analysis, and bronchoprovocation tests (BPTs). We focus on their applicability for monitoring in clinical practice and in intervention trials in asthma.

Keywords

LTRA BAL LTB4 ASM iNOS EBC eNO ERS Cysteinyl leukotrienes ICS LTS ECP DTT cNOS AMP ATS BPT Cys-LTs PC20 Mmps bronchoprovocation test AHR FEV1 MPO inducible NO synthase Hydrogen peroxide Clinical trials Asthma leukotriene receptor antagonists Airway inflammation European Respiratory Society American Thoracic Society exhaled nitric oxide enzyme immunoassay EIA Carbon dioxide dithiothreitol TIMP Platelet activating factor Airway smooth muscle provocative concentration causing a 20% fall in FEV1 Lar bronchoalveolar lavage Leukotriene B4 Leukotrienes Exhaled breath condensate Matrix metalloproteinases forced expiratory volume in 1 second Tissue inhibitor of metalloproteinases myeloperoxidase Nitric oxide PAF H2O2 Early asthmatic response Late asthmatic response Airway hyperresponsiveness Eosinophil cationic protein CO2 Inhaled corticosteroids EAR