Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2567803 | Pulmonary Pharmacology & Therapeutics | 2008 | 7 Pages |
Abstract
The present study was designed to determine the effect of various core temperatures on acute lung injury induced by ischemia-reperfusion (I/R) in our isolated rabbit lung model. Typical acute lung injury was successfully induced by 30Â min of ischemia followed by 90Â min of reperfusion observation. The I/R elicited a significant increase in pulmonary arterial pressure, microvascular permeability (measured by using the capillary filtration coefficient, Kfc), ÎKfc ratio, lung weight gain and the protein concentration of the bronchoalveolar lavage fluid. Mild hypothermia significantly attenuated acute lung injury induced by I/R, all parameters having decreased significantly (p<0.05); conversely, mild hyperthermia did not further exacerbate acute lung injury. These experimental data suggest that mild hypothermia significantly ameliorated acute lung injury induced by ischemia-reperfusion in rabbits.
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Authors
Hung Chang, Kun-Lun Huang, Min-Hui Li, Ching-Wang Hsu, Shih-Hung Tsai, Shi-Jye Chu,