| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2568803 | Toxicology and Applied Pharmacology | 2013 | 9 Pages |
Abstract
⺠DHEA, produced by CYP17, plays a key role in sexual functioning and development. ⺠No rapid screening assay for effects on CYP17 is available yet. ⺠A novel assay using porcine adrenal cortex microsomes (PACMs) was described. ⺠Endocrine disrupting compounds (EDCs) targeting CYP17 interact differently with CYP19. ⺠A specific CYP17 assay is a valuable screening for effects early in steroidogenesis.
Keywords
PFBSCYP11Adibutyl phthalateEC50epicatechinEDSPH295RDEHPOECDTBBPAdehydroepiandrosteroneGlufosinate ammoniumCYP17EPIRIAMEHPforskolinMAADMLKETGPAESFPFNABPAmono-ethylhexyl phthalatePerfluorohexane sulfonic acidDHEAtetrabromobisphenol AMMCPFOAMPWPFOSIC50ATZcytochrome P450 17TCSDBPcyclic AMPcAMPd-mannitolEDCsUS EPAatrazineforward primerEndosulfanEndocrine disruptorsDESEstradiolSteroidogenesisPerfluorononanoic acidMethoxyacetic acidCSAFOREndocrine Disruptor Screening ProgramBisphenol AEndocrine disrupting compoundsTriclosanELISAtestosteroneTebuconazoleDiethylhexyl phthalateDiethylstilbestrolradioimmunoassayRetinoic acidOrganization for Economic Cooperation and DevelopmentFlucyclosporin AFlusilazoleGenisteinMethylmercuryreverse primerhalf maximal inhibitory concentrationhalf maximal effective concentrationRepPerfluorooctanoic acidGENKetoconazole
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Authors
Maarke J.E. Roelofs, Aldert H. Piersma, Martin van den Berg, Majorie B.M. van Duursen,