| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2568876 | Toxicology and Applied Pharmacology | 2012 | 9 Pages |
Abstract
⺠Lack of Nrf2 reduced expression of antioxidant genes induced by iAs3 + in β-cells. ⺠Deficiency of Nrf2 in β-cells sensitized to iAs3 + and MMA3 +-induced cytotoxicity. ⺠Nrf2 activation protected β-cells from acute iAs3 + cytotoxicity.
Keywords
SFNsulfiredoxin 1Nrf2−/−Inorganic arseniteSrxGSISNAD(P)H: quinone oxidoreductase 1tert-butylhydroquinoneGCLCNQO1HMOX1T1DT2DiAs18SNrf2PBSDMEMFBSTBHQDulbecco's modified Eagle's medium18S ribosomal RNAROSPancreatic β-cellArsenicInorganic arsenicDimethylarsinous acidMonomethylarsonous acidDiabetesGlucose-stimulated insulin secretionOxidative stressIsletsType 2 diabetesType 1 diabetesfetal bovine serumCytotoxicitySulforaphanenuclear factor E2-related factor 2antioxidant response elementPhosphate buffered salineAREheme oxygenase 1Propidium iodideReactive oxygen species
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Authors
Bei Yang, Jingqi Fu, Hongzhi Zheng, Peng Xue, Kathy Yarborough, Courtney G. Woods, Yongyong Hou, Qiang Zhang, Melvin E. Andersen, Jingbo Pi,