| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2568971 | Toxicology and Applied Pharmacology | 2013 | 7 Pages |
Abstract
⺠Proteomic analysis identified novel FXR targets. ⺠FXR modification altered post-translational modification of the Parp1 protein. ⺠Altered Parp1 function may contribute to mechanisms of FXR regulation of liver functions.
Keywords
ALDH2mitochondrial aldehyde dehydrogenase 2ENO1ALC1PARP1HAAOFXRCDCAIPASHP2D-DIGEfarnesoid X receptorHCCq-PCRChenodeoxycholic acidpost-translational modificationtwo-dimensional gel electrophoresisIngenuity Pathway Analysissmall heterodimer partnerMiceIsoelectric pointwild-typequantitative real-time PCRProteomicsHepatocellular carcinomaNuclear receptor
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Authors
Yan Zhu, Guodong Li, Yafeng Dong, Helen H. Zhou, Bo Kong, Lauren M. Aleksunes, Jason R. Richardson, Fei Li, Grace L. Guo,