Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2569036 | Toxicology and Applied Pharmacology | 2012 | 8 Pages |
Abstract
⺠Calcium channel blockers (CCB) are antiproliferative in vascular smooth muscle cells. ⺠Verapamil stereoisomers are antiproliferative in VSMC independent of CCB activity. ⺠Verapamil stereoisomers alter mitochondrial appearance and frequency in VSMC. ⺠Verapamil stimulates autophagy in cultured VSMC.
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Authors
Joshua K. Salabei, Arun Balakumaran, Justin C. Frey, Paul J. Boor, Mary Treinen-Moslen, Daniel J. Conklin,