| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2569199 | Toxicology and Applied Pharmacology | 2011 | 9 Pages |
Abstract
⺠PBDE congeners are substrates of OATPs expressed in human hepatocytes. ⺠Mice are commonly used to study the toxicity of chemicals like the PBDE congeners. ⺠Oatp1a4, Oatp1b2, and Oatp2b1 transported all three PBDE congeners in vitro. ⺠In vivo Oatp1a4 plays a minor and Oatp1b2 a major role in BDE47 liver accumulation.
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Authors
Erik Pacyniak, Bruno Hagenbuch, Curtis D. Klaassen, Lois Lehman-McKeeman, Grace L. Guo,