| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2569273 | Toxicology and Applied Pharmacology | 2012 | 9 Pages |
Abstract
⺠DES induced adipocyte differentiation in a dose-dependent manner in 3T3-L1 cells. ⺠DES activated adipogenic critical regulators and markers in vitro and in vivo. ⺠Perinatal exposure to DES led to the obese phenotype in female offspring. ⺠DES might be a potential chemical stressor for obesity and obesity-related disorders.
Keywords
SREBF1LPLAP2ERRPNDFASPPARγC/EBPαCCAAT/enhancer-binding protein alphaEDCsDESTriglyceridesAdipocyte differentiationintraperitonealDiethylstilbestrolpostnatal dayPerinatal exposureLipoprotein lipaseObesityEndocrine Disrupting ChemicalsPVCPolyvinyl chloridePeroxisome proliferator-activated receptor gammaEstrogen receptorestrogen-related receptor
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Authors
Chan-Juan Hao, Xue-Jia Cheng, Hong-Fei Xia, Xu Ma,