| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2569344 | Toxicology and Applied Pharmacology | 2011 | 9 Pages |
Abstract
⺠DBC activation via CYP3A4 resulted in micronuclei, DNA adduct formation and mutations in V79MZh3A4 cells. ⺠The CYP3A4-mediated DiMeDBC activation caused micronuclei followed by apoptosis in V79MZh3A4 cells. ⺠The genotoxic effects produced by N-MeDBC in V79MZh3A4 cells were negligible. ⺠The hCYP3A4 may play an important role in DBC and DiMeDBC metabolism. ⺠The CYP3A4 might only have a marginal function in N-MeDBC metabolism.
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![The role of human cytochrome P4503A4 in biotransformation of tissue-specific derivatives of 7H-dibenzo[c,g]carbazole](/preview/png/2569344.png "First Page Preview: The role of human cytochrome P4503A4 in biotransformation of tissue-specific derivatives of 7H-dibenzo[c,g]carbazole")
Authors
Monika MesároÅ¡ová, Zuzana ValoviÄová, Annamária SranÄÃková, Zdenka KrajÄoviÄová, Alena Milcová, Romana Sokolová, Jana Schmuczerová, Jan Topinka, Alena Gábelová,