Effect of baicalin on toll-like receptor 4-mediated ischemia/reperfusion inflammatory responses in alcoholic fatty liver condition

Article ID	Journal	Published Year	Pages	File Type
2569405	Toxicology and Applied Pharmacology	2012	8 Pages	PDF

Abstract

âº Baicalin attenuates hepatic I/R-induced inflammation in alcoholic fatty liver. âº Baicalin downregulates TLR4, MyD88 expression during I/R in alcoholic fatty liver. âº Baicalin attenuates NF-ÎºB nuclear translocation during I/R in alcoholic fatty liver.

Keywords

NF-κB Baicalin HMGB1 TLR PAMP iNOS COX-2 DAMP High-mobility group box1 MYD88 IL-6 I/R inflammation Danger-associated molecular pattern pathogen-associated molecular pattern ischemia/reperfusion interleukin-6 triglyceride tumor necrosis factor-α Toll-like receptor control diet inducible nitric oxide synthase Cyclooxygenase-2 myeloid differentiation factor 88 TNF-α nuclear factor-κB alcoholic fatty liver