| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2569512 | Toxicology and Applied Pharmacology | 2011 | 8 Pages |
Abstract
⺠Altered Ca2+ homeostasis leads to arsenic-induced HKM apoptosis. ⺠Calpain-2 plays a critical role in the process. ⺠ERK is pro-apoptotic in arsenic-induced HKM apoptosis. ⺠Arsenic-induced HKM apoptosis involves cross talk between calpain-2 and ERK.
Keywords
c-Jun NH2-terminal kinaseDPIHRPTBSNACEGTANADPHERKPMSFDTTTMBMS222PVDFNaOHRPMI-1640Ac-DEVD-choFBSJnk3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonatePhosphorylated ERKMAPKROSAlkaline phosphataseapoApocyninEDTAethylenediamine tetraacetic acidSDS-PAGETris buffered salinediphenyleneiodonium chloridedithiothreitolfetal bovine serumPipesErk inhibitorN-acetyl cysteinesodium hydroxideVerapamilHorseradish peroxidasemitogen activated protein kinasePERKPoly vinylidene fluorideCHAPSextracellular signal-regulated kinaseReactive oxygen species
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Authors
Chaitali Banerjee, Ramansu Goswami, Soma Datta, R. Rajagopal, Shibnath Mazumder,