Article ID Journal Published Year Pages File Type
2569575 Toxicology and Applied Pharmacology 2011 9 Pages PDF
Abstract
► GSE attenuated arsenic-induced low antioxidant defense, oxidative damage, proinflammatory cytokines and fibrogenic genes. ► GSE reduced arsenic-mediated Smad2/3 phosphorylation and NADPH oxidase subunits (Nox2, Nox4 and p47phox). ► Beneficial effects of GSE on As-induced liver injury was via inhibition of NADPH oxidase and TGF-β/Smad activation.
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Related Topics
Life Sciences Environmental Science Health, Toxicology and Mutagenesis
Preview
Inhibition of arsenic induced-rat liver injury by grape seed exact through suppression of NADPH oxidase and TGF-β/Smad activation
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