| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2569653 | Toxicology and Applied Pharmacology | 2011 | 11 Pages |
Abstract
⺠The anti-fibrotic effects of imatinib, nilotinib and silymarin were compared. ⺠These effects were evaluated on CCl4-induced hepatic fibrosis in rats. ⺠Nilotinib was found to possess potent anti-fibrotic activity. ⺠In addition, nilotinib did not show any signs of hepatotoxicity. ⺠Thus, nilotinib may be valuable in the treatment of hepatic fibrosis in humans.
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Authors
Mohamed E. Shaker, Khaled R. Zalata, Wajahat Z. Mehal, Gamal E. Shiha, Tarek M. Ibrahim,