Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2570515 | Toxicology and Applied Pharmacology | 2009 | 10 Pages |
Abstract
CsA modifies mitochondrial LLC-PK1 cell physiology with loss of negative electrochemical gradient across the inner mitochondrial membrane and increased lipid peroxidation. These features are related to apoptosis and can explain the cellular damage that CsA induces. As Vit E inhibited these effects, our results suggest that they were mediated by an increase in ROS production by mitochondria.
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Authors
G. de Arriba, J. Pérez de Hornedo, S. RamÃrez Rubio, M. Calvino Fernández, S. Benito MartÃnez, M. Maiques Camarero, T. Parra Cid,