| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2574448 | Vascular Pharmacology | 2009 | 9 Pages |
Abstract
Ang II effects are transient due to desensitization and cause tachyphylaxis to Ang II and toward Ang II-POL suggesting that both Ang II and Ang II-POL act on the same receptor group. In contrast, Ang II-POL effects are sustained and do not cause tachyphylaxis. The results show that intravascular Ang II and Ang II-POL act differentially by an unknown mechanism on CELM's AT1R and suggest that intravascular Ang II and Ang II-POL cause PIE and CCP by activation limited to CELM's AT1R through an unknown mechanism that is space-confined to the CELM's AT1R.
Keywords
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Authors
Jesús Castillo-Hernández, David Torres-Tirado, Alma Barajas-Espinosa, Erika Chi-Ahumada, Juan Ramiro-DÃaz, Guillermo Ceballos, Rafael Rubio,