Effect of acetyl 11-keto β-boswellic acid on metastatic growth factor responsible for angiogenesis

Basic fibroblast growth factor (bFGF), a metastatic growth factor is known to be one of the promoting factors in the tumor induced angiogenesis. The antiangiogenic activity of acetyl 11-keto β-boswellic acid was screened against bFGF-induced angiogenesis using in-vivo Matrigel Plug Assay. Histological & colorimetric examination confirmed that numerous blood vessels were present in Matrigel + bFGF group in comparison to Matrigel alone treated mice. Acetyl 11-keto β-boswellic acids (10 mg/kg/d) inhibited the Matrigel + bFGF-induced angiogenesis significantly (P < 0.01) in contrast to anti-inflammatory agent indomethacin (10 mg/kg/d) and alkylating agent cyclophosphamide (10 mg/kg/d).