| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2575473 | World Science and Technology | 2008 | 4 Pages |
ObjectiveTo explore the effects of Qingkailing injection (QKL) on transforming growth factor-β1 (TGF-β1) expression in the rats with cerebral ischemia-reperfusion injury.MethodsHealthy Wistar rats were randomly divided into 3 groups: normal group, model group, and QKL-treated group. Model of cerebral ischemia-reperfusion injury was copied by repeated occlusion of common carotid arteries (CCA) on both sides. The expression of glial fibrillary acidic protein (GFAP) and TGF-β1 in brain tissue was observed at different time intervals, using immunity histochemistry staining method.ResultsAt different time intervals after cerebral ischemia-reperfusion injury, the expression of GFAP and TGF-β1 in brain tissue increased by different degrees, whereas QKL decreased them by different degrees.ConclusionQKL could probably reduce the expression of TGF-β1 by restraining the activity of astrocytes (AST).
