A comparison of four methods to quantify the cumulative effect of taking multiple drugs with sedative properties

Conclusions: Evidence is accumulating in relation to a range of adverse outcomes associated with using multiple drugs with sedative properties. However, no studies have been conducted using>1 method to quantify the cumulative effect of taking multiple drugs with sedative properties. Each method has likely advantages and disadvantages. The usefulness of each method in clinical practice remains to be determined. The models must be validated in different populations of older people and may subsequently need to be refined.