Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2576102 | The American Journal of Geriatric Pharmacotherapy | 2006 | 11 Pages |
Abstract
This pooled analysis of 50 published and unpublished studies in elderly patients found that the overall prevalences of AEs did not appear to increase with dose and appeared comparable to that observed with placebo. Although the prevalences of ALT/AST elevations appeared slightly higher in the 80-mg/d group (3.2% vs â¤0.9% in all other groups), specific musculoskeletal and hepatic AEs were rare (â¤3.0%). The rates of discontinuation appeared comparable between all 4 doses of atorvastatin and placebo. The results of this analysis support the favorable safety profile of atorvastatin across the full dose range in patients aged â¥65 years.
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Authors
DDS, MD Hey-Hadavi, MD Kuntze, PhD Luo, PharmD Silverman, PharmD Pittman, MD LePetri,