| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2576391 | International Congress Series | 2007 | 4 Pages |
Abstract
Indoleamine 2,3-dioxygenase (IDO)-initiated tryptophan (Trp) metabolism along the kynurenine (Kyn) pathway regulates T cell responses. However, it is not clear whether bone marrow-derived myeloid dendritic cells (BMDC) express functional IDO. In this study, BMDC expressed IDO protein with nitric oxide (NO) production by CpG oligodeoxynucleotides (CpG), and the CpG-mediated induction of IDO activity in BMDC was severely down-regulated by NO. The error in the estimation of Kyn assay was induced by the reaction of Kyn with nitrite under acidic conditions.
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Authors
Toshiaki Hara, Rie Hiramatsu, Hidetoshi Akimoto, Osamu Takikawa, Tsutomu Kawabe, Fumihiko Nagase,