Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2576792 | International Congress Series | 2006 | 8 Pages |
Abstract
Growth hormone (GH), its receptor and signaling cascade and the insulin-like growth factor (IGF) system are important regulators of growth and metabolic homeostasis. The GH–IGF axis in girls and women with Turner syndrome has been studied by many groups. A variety of distinct abnormalities as to synthesis and secretion of GH and IGFs as well as perturbed signaling and impaired biologic responses to GH and/or IGFs have been reported. This chapter summarizes the literature and gives a synopsis of current knowledge as to findings related to the GH and IGF system in girls and women with Turner syndrome.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Molecular Biology
Authors
Wieland Kiess, Jurgen Kratzsch, Roland Pfaeffle,