Evaluación de la eficacia del cribado prenatal combinado del primer trimestre de embarazo. Nuestra experiencia en el periodo 2010-2013

This article describes the diagnostic efficacy with the combined prenatal screening in the first trimester for the detection of chromosomal abnormalities, in the San Juan de la Cruz (Ubeda, Jaén) Hospital, in the period 2010-2013, in a population of 4503 pregnant. The sensitivity was 81%, the specificity was 96.6%, PPV 10%, NPV 99.9% and the false positive rate was 3.38%. The detection rate, in the group of pregnant women over 35 years, was 92% and false positive rate was 9.01%, while in the group of pregnant women under 35 years, the detection rate and false positives was 62.5% and 1.9% respectively. The realization of a contingent screening may increase the detection rate among women younger than 35 years and on the other hand decrease the false positive rate in older women as well as the number of invasive tests to realise.