| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2578514 | Revista del Laboratorio Clínico | 2009 | 6 Pages |
Abstract
Platelets subjected to shearing become refractory when they are subsequently activated by action of a physiological agonist such as ADP. However the platelets that are not sheared respond appropriately to this agonist. This refractory response in vitro may represent a cellular defence mechanism to prevent a greater degree of in vivo activation-aggregation when platelets are faced with an agonist in areas where the shear rate increases in the blood flow.
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Authors
Sandra Dolz Giménez, Marcial MartÃnez Silvestre,