| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2581329 | Chemico-Biological Interactions | 2011 | 12 Pages |
Abstract
⺠Effects of 4-hydroxynonenal (HNE) on esterase and lipase activities was examined. ⺠Hydrolytic activities of pure CES enzymes and intact cells are inhibited by HNE. ⺠Lysine 105 in recombinant CES1 enzyme was covalently modified by HNE. ⺠THP1 cells efficiently metabolize HNE and yield glutathione-HNE conjugates.
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Authors
Abdolsamad Borazjani, Mariola J. Edelmann, Katelyn L. Hardin, Katye L. Herring, J. Allen Crow, Matthew K. Ross,