Article ID Journal Published Year Pages File Type
2581589 Chemico-Biological Interactions 2008 5 Pages PDF
Abstract
These results demonstrate that donepezil has protective effects against ischemic damage, glutamate excitotoxicity and Aβ toxicity to rat primary cultured neurons and these effects are not dependent on acetylcholinesterase inhibition and antagonism of NMDA receptors. Thus, donepezil is expected to have a protective effect against progressive degeneration of brain neuronal cells in ischemic cerebrovascular disease and Alzheimer's disease.
Keywords
Related Topics
Life Sciences Environmental Science Health, Toxicology and Mutagenesis
Authors
, , , , ,