| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2582821 | Environmental Toxicology and Pharmacology | 2016 | 9 Pages |
•Single dose of ARI (1.5 mg/kg) and OLA (0.5 mg/kg) produced alternation in neurotransmitters level.•Both drugs increase the level of DA and 5-HT in the frontal cortex of rats.•ARI and OLA administration also increase the DA metabolites level—DOPAC and HVA.•Increased 5-HIAA level was observed only following the administration of ARI.•Only single dose of OLA increased the level of NA observed in frontal cortex.
ObjectivesThe study aims to verify whether alterations in the level of neurotransmitters have occurred in prenatally stressed rats (animal model of schizophrenia), and whether aripiprazole (ARI) and olanzapine (OLA) modify this level.MethodsThe effects of ARI (1.5 mg/kg) and OLA (0.5 mg/kg) were studied by means of microdialysis in freely moving rats (observation time 120 min). The level of neurotransmitters (DA, 5-HT, NA) and their metabolites (DOPAC, HVA, 5-HIAA) was analyzed by HPLC with coulochemical detection.ResultsObtained results indicate that after a single administration of ARI and OLA in the prenatally stressed rats the increase of DA, DOPAC, and 5-HT was observed. In turn ARI administration increase the level of HVA and 5-HIAA and also decrease the level of NA. After OLA administration the level of NA and HVA increased and no significant change in 5-HIAA was observed.ConclusionAlterations observed as a result of ARI and OLA administration may be pivotal in identifying animal models of mental disorders and in the analysis of neuroleptics effectiveness.
