| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2582933 | Environmental Toxicology and Pharmacology | 2015 | 5 Pages |
•Enrofloxacin (ENR) and chlorpyrifos (CPF) reduce the content of vitamins A and E in the liver.•CPF significantly decreased vitamins A and E level in the initial period of the experiment.•Co-exposure to ENR and CPF resulted in less pronounced changes compared to CPF administration only.•The vitamin levels did not reach the control values until the completion of the study.
This study investigates the effects of enrofloxacin and chlorpyrifos, and their combination on vitamin A and E concentrations in the liver of rats. Results of this study indicated a reduction in the contents of vitamins A and E in the liver, which persisted for the entire period of the experiment. Vitamins A and E concentrations were slightly decreased (2–7%) in enrofloxacin-treated rats. In the group of rats intoxicated with chlorpyrifos, a significant decrease in the level of vitamin A was observed up to the 24th hour, and for vitamin E up to the 3rd day from the discontinuation of intoxication with the compounds under study. In the enrofloxacin-chlorpyrifos co-exposure group reduced vitamins A and E level was also noted. The greatest fall in vitamin A level was observed after 3 h, while the contents of vitamin E decreased progressively up to the 3rd day. Changes in this group were less pronounced in comparison to the animals intoxicated with chlorpyrifos only.
