Gallic acid: Molecular rival of cancer

Gallic acid, a predominant polyphenol, has been shown to inhibit carcinogenesis in animal models and in vitro cancerous cell lines. The inhibitory effect of gallic acid on cancer cell growth is mediated via the modulation of genes which encodes for cell cycle, metastasis, angiogenesis and apoptosis. Gallic acid inhibits activation of NF-κB and Akt signaling pathways along with the activity of COX, ribonucleotide reductase and GSH. Moreover, gallic acid activates ATM kinase signaling pathways to prevent the processes of carcinogenesis. The data so far available, both from in vivo and in vitro studies, indicate that this dietary polyphenol could be promising agent in the field of cancer chemoprevention.

► The inhibitory effects exerted by gallic acid (GA) on cancerous cells. ► Inhibition of COX-2, Ribonucleotide Reductase, GSH and UGDH. ► The molecular mechanisms of apoptosis induction and angiogenesis inhibition by GA. ► Anticancerous effect of gallic acid derivatives.