| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2583225 | Environmental Toxicology and Pharmacology | 2013 | 7 Pages |
Abstract
⺠OPI structural requirements to inhibit kynurenine formamidase investigated by 3D QSAR. ⺠Enzyme of chicken yolk sac membranes targeted with respect to OPI teratogenesis. ⺠Electrostatic and steric fields found as best predictors of OPI inhibitory potency. ⺠Electronegativity around pyrimidinyl nitrogens makes pyrimidinyl OPI best inhibitors. ⺠Specific structural features that make some OPI superior inhibitors outlined.
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Authors
Josef Seifert,