Article ID Journal Published Year Pages File Type
2583227 Environmental Toxicology and Pharmacology 2013 10 Pages PDF
Abstract

The current work aimed to investigate the different toxic effects of chlorpyrifos (CPF) in subchronic exposure. Two groups of Sprague-Dawley male rats were exposed to CPF alone in a dose of 30 mg/kg body weight, or CPF dose as previous plus glutathione (GSH) in a dose of 100 mg/kg body weight, for 90 days, twice weekly, orally. Another two groups of rat were given corn oil (control) or GSH. There is a significant decrease in hemoglobin concentration, haematocrit percentage, thrombocytic indices, total protein and albumin levels in CPF-exposed group. CPF induced hyperglycemia and significant increase in total cholesterol, but a significant decrease in triglyceride levels was obtained. A significant increase in the levels of lipid peroxidation was obtained while a significant decrease of the total antioxidant was recorded. The decrease in glycogen content and some histopathological changes were observed in liver after CPF exposure. Furthermore, co-administration of GSH can restore some of these alterations.

► Sub chronic exposure to chlorpyrifos in rat. ► Determination of hematological, metabolic and oxidative status. ► Chlorpyrifos induced hyperglycaemia and increase in total cholesterol but decrease in triglyceride levels. ► Chlorpyrifos induced liver damage. ► Chlorpyrifos induced oxidative stress. ► Co-treatment with glutathion can ameliorate the multiple toxic effects induced by chlorpyrifos.

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Life Sciences Environmental Science Health, Toxicology and Mutagenesis
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