| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2583244 | Environmental Toxicology and Pharmacology | 2013 | 5 Pages |
1-nitropyrene (1-NP), a common PAH in diesel exhaust, and its amine metabolite 1-aminopyrene (1-AP) induce distinctly different chemokine-responses in bronchial epithelial cells (BEAS-2B) characterized by increases in CXCL8 and CCL5, respectively. Tumor necrosis factor-α converting enzyme (TACE), which cleaves membrane-bound transforming growth factor (TGF)-α, activating the epidermal growth factor receptor (EGFR), may regulate pro-inflammatory responses induced by a variety of endogenous and exogenous agents. The present results suggest that CXCL8, but not CCL5 responses in 1-NP- or 1-AP-exposed cells required TACE/TGF-α/EGFR-signaling. The findings strengthen the notion that TACE/TGF-α/EGFR-signaling is central in epithelial CXCL8-regulation upon exposure to multiple airborne pollutants.
► NP induced a strong CXCL8-response but not CCL5 in BEAS-2B cells. ► AP induced a moderate increase in both CXCL8 and CCL5 in BEAS-2B cells. ► TACE/TGF-α/EGFR-signaling was crucial to induction of CXCL8, but not CCL5. ► EGFR may also have a TACE/TGF-α -independent role in regulation of both chemokines. ► TACE and EGFR may be central regulators of inflammation by multiple air pollutants.
