| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2583515 | Environmental Toxicology and Pharmacology | 2012 | 10 Pages |
Abstract
⺠We evaluated effects of arsenic preexposure on the pharmacodynamics of ketoprofen. ⺠Arsenic inhibited analgesic, anti-inflammatory and antipyretic effects of ketoprofen. ⺠Arsenic attenuated ketoprofen's effects on COX activity and TNF-α, IL-1β and PGE2 levels. ⺠Inhibitory effects of arsenic may link to functional antagonism of ketoprofen. ⺠Arsenic exposure via drinking water may reduce ketoprofen's therapeutic efficacy.
Keywords
GMCSFTgf-αLPSCOXPGE2NSAIDcAMPgranulocyte/macrophage colony-stimulating factorCyclic adenosine monophosphateArseniccyclooxygenaseinflammationinterleukintransforming growth factor-alphatumor necrosis factor-alphanonsteroidal anti-inflammatory drugPainTNF-αlipopolysaccharideRatsProstaglandin E2Pyrexiaketoprofen
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Authors
Wasif Ahmad, Shahid Prawez, H.H. Chanderashekara, Surendra Kumar Tandan, Palanisamy Sankar, Souvendra Nath Sarkar,