Octaphlorethol A isolated from Ishige foliacea prevents and protects against high glucose-induced oxidative damage in vitro and in vivo

•This study was designed to assess in vitro and in vivo protective effect of octaphlorethol A.•Protective effect against at the high glucose-induced cell and zebrafish model.•Octaphlorethol A possesses a protective effect against high glucose induced oxidative stress.

We investigated the protective effect of octaphlorethol A (OPA) isolated from Ishige foliacea against high-glucose-induced oxidative damage, as indicated by reactive oxygen species (ROS) generation, lipid peroxidation, and cell death, in human umbilical vein endothelial cells (HUVECs) and in a zebrafish model. OPA treatment significantly and dose-dependently decreased ROS generation, lipid peroxidation, and cell death in HUVECs and in a zebrafish model. Our results show that OPA can protect HUVECs and zebrafish against high glucose by suppressing intracellular ROS generation, lipid peroxidation, and cell death.