Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2584508 | Environmental Toxicology and Pharmacology | 2006 | 6 Pages |
Abstract
Our study investigated the possible protective effects of coenzyme Q10 (CoQ10) and Vitamin E (Vit E) alone or in combination against cadmium (Cd) induced alterations of antioxidant defense system in the rat heart. Male Wistar rats were injected with a single dose of CdCl2 (0.4Â mg Cd/kg BW i.p.), CoQ10 (20Â mg CoQ10/kg BW i.m.) and Vit E (20Â IU Vit E/kg BW i.m.), alone or in combination. Acute intoxication of rats with Cd were followed by significantly increased activity of antioxidant defense enzymes (CuZn SOD, GSH-Px, GST and GR), while the activity of Mn SOD was decreased in the heart. The treatment with Cd significantly decreased Vit C and Vit E concentrations. Treatment with CoQ10 and Vit E reversed Cd-induced alterations of antioxidant defense system. The obtained results support the assumption that CoQ10 and Vit E functions cooperatively with endogenous antioxidants and diminished toxic effects of Cd in rat heart.
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Authors
Branka I. OgnjanoviÄ, Snežana D. MarkoviÄ, Sladjan Z. PavloviÄ, Radoslav V. ŽikiÄ, AndraÅ¡ Å . Å tajn, Zorica S. SaiÄiÄ,